Glutamine replaced by valine in sckle cell anaemia is characterized________________?
Correct answer: D. Missense mutation of beta chain
- A. Non Sense mutation of beta chain
- B. Deletion of beta chain
- C. Degradation of beta chain
- D. Missense mutation of beta chain
Explanation
Sickle-cell disease results from replacement of glutamic acid by valine in the β-globin chain, which changes one amino acid and therefore represents a missense mutation. The stem incorrectly says glutamine instead of glutamic acid.
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