Moderate

Glutamine replaced by valine in sckle cell anaemia is characterized________________?

Correct answer: B. Missense mutation of beta chain

  • A. Non Sense mutation of beta chain
  • B. Missense mutation of beta chain
  • C. Degradation of beta chain
  • D. Deletion of beta chain

Explanation

Sickle-cell disease results from replacement of glutamic acid by valine in the β-globin chain, which changes one amino acid and therefore represents a missense mutation. The stem incorrectly says glutamine instead of glutamic acid.

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