Following events are associated with a lysosomal disorder called Tay Sach's disease. Arrange them in a specific sequence with respect to their occurrence:i. Mental retardationii. Inheritance of abnormal geneiii. Accumulation of lipids in brain cellsiv. Lack of catabolism of lipidsv. Absence of an enzyme
Correct answer: D. ii, v, iv, iii, i
- A. i, ii, iii, iv, v
- B. v, iv, iii, ii, i
- C. ii, iv, i, iii, v
- D. ii, v, iv, iii, i
Explanation
The correct sequence for the events in Tay-Sachs disease is: ii, v, iv, iii, i. The disease begins with the inheritance of an abnormal gene (ii), which affects the synthesis of a specific lysosomal enzyme, leading to its absence (v). Without this enzyme, the catabolism of lipids is impaired (iv), resulting in their accumulation in brain cells (iii). This biochemical dysfunction ultimately manifests as mental retardation (i). Incorrect options either start with the wrong event or misplace the sequence of the biochemical and genetic progression.
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