Following drug which undergo most of its metabolism presystemically______________?
Correct answer: C. Propranolol
- A. Salbutamol
- B. Verapamil
- C. Propranolol
- D. Paracetamol
Explanation
Propranolol undergoes marked hepatic first-pass metabolism, so its oral bioavailability is relatively low and variable. Verapamil also has substantial first-pass metabolism, but propranolol is the classic answer in this comparison.
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