Following drug which undergo most of its metabolism presystemically______________?

Correct answer: C. Propranolol

  • A. Salbutamol
  • B. Verapamil
  • C. Propranolol
  • D. Paracetamol

Explanation

Propranolol undergoes marked hepatic first-pass metabolism, so its oral bioavailability is relatively low and variable. Verapamil also has substantial first-pass metabolism, but propranolol is the classic answer in this comparison.

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