During a routine checkup a 70 year old male is found to have Serum Alkaline Phosphatase three time the upper limit of normal. Serum Calcium, Serum Phosphorous and liver function tests are normal. The most likely diagonsis is______________?
Correct answer: D. Paget's disease of the bone
- A. Primary hyperparathyroidism
- B. Metastatic bone disease
- C. Osteomalacia
- D. Paget's disease of the bone
Explanation
An isolated marked rise in alkaline phosphatase with normal calcium, phosphate, and liver tests in an elderly patient strongly suggests Paget disease of bone. Hyperparathyroidism and osteomalacia commonly disturb mineral levels, while metastatic disease is less characteristic of this laboratory pattern.
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