Consider the given metabolic reactions I and II.In the metabolic reaction II, product is NOT formed because malonate acts as a/an
Correct answer: C. competitive inhibitor
- A. allosteric inhibitor
- B. irreversible inhibitor
- C. competitive inhibitor
- D. non-competitive inhibitor
Explanation
Malonate is a competitive inhibitor, which means it competes with the substrate for the active site of the enzyme. In the context of metabolic reactions, when malonate is present, it binds to the active site of the enzyme instead of the substrate, preventing the formation of the product. This is why in metabolic reaction II, the product is NOT formed. Competitive inhibition can be overcome by increasing the concentration of the substrate.Allosteric inhibitors, on the other hand, bind to a site other than the active site, inducing a conformational change that reduces enzyme activity. Irreversible inhibitors form covalent bonds with enzymes, leading to permanent inhibition, while non-competitive inhibitors reduce enzyme activity by binding elsewhere and are not affected by substrate concentration.
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About Enzyme Inhibitors
Enzyme inhibitors reduce reaction rate by interfering with enzyme-substrate interaction or catalytic activity. Coverage includes reversible competitive, non-competitive and uncompetitive inhibition, the effects of inhibitor concentration on reaction rate, and why competitive inhibition can be reduced by increasing substrate concentration.
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