Asked in KMU MDCAT 2023 (retake) 2023Moderate

Compound X reacts with Grignard's reagent to produce tertiary alcohols. What is the compound?

Correct answer: B. Ketone

  • A. Aldehyde
  • B. Ketone
  • C. Acid halide
  • D. Carboxylic acid

Explanation

Grignard's reagent (RMgX) reacts with ketones to produce tertiary alcohols. The reaction involves the nucleophilic addition of the Grignard reagent to the carbonyl group of the ketone, followed by hydrolysis to form a tertiary alcohol.The reaction is:R2C=O (ketone) + RMgX (Grignard reagent) → R2C(OH)R' (tertiary alcohol)

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About Nucleophilic Addition Reactions

Nucleophilic addition occurs at the polar carbonyl group of aldehydes and ketones, where a nucleophile attacks the electron-deficient carbon atom. Reactions with hydrogen cyanide, sodium bisulfite, alcohols and Grignard reagents are explained through tetrahedral intermediates, acid or base catalysis, and the different reactivity of aldehydes and ketones.

Practise Aldehydes and Ketones

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