Cells from an advanced malignant tumor most often have very abnormal chromosomes, and often an abnormal total number of chromosomes. Why might this occur?
Correct answer: C. Chromosomally abnormal cells can still go through cell cycle checkpoints
- A. Cancer cells are no longer density dependent
- B. Cancer cells are no longer anchorage dependent
- C. Chromosomally abnormal cells can still go through cell cycle checkpoints
- D. Transformation introduces new chromosomes into cells
Explanation
Aneuploidy, characterized by an abnormal number of chromosomes, is a common feature of cancer cells. It can result from errors in chromosome segregation during cell division, leading to unequal distribution of chromosomes to daughter cells. Despite being chromosomally abnormal, cancer cells may still bypass cell cycle checkpoints due to dysregulation of cell cycle control mechanisms.
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