At PH 7 the binding of 2,3 DPG to hemoglobin occurs at which site ?
Correct answer: C. Amino terminal
- A. Sulphydryl group
- B. Carboxy terminal
- C. Amino terminal
- D. Histidine
Explanation
At physiological pH, 2,3-DPG binds in the positively charged central cavity between haemoglobin's beta chains, interacting mainly with amino-terminal residues. This stabilises deoxyhaemoglobin and promotes oxygen release.
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