Anti retroviral drugs such as zidovudine (AZT) slow the progress of HIV infection by
Correct answer: C. inhibiting the enzyme reverse transcriptase
- A. dissolving the lipid envelope of the virus
- B. stimulating plasma cells to make more antibody
- C. inhibiting the enzyme reverse transcriptase
- D. killing the infected helper T cells before the virus matures
Explanation
AZT is a nucleoside analogue that reverse transcriptase inserts into the growing DNA chain, after which the chain cannot be extended, so no provirus is made. Because the enzyme is viral and has no human counterpart, the drug harms the virus far more than the patient. Such drugs suppress replication and prolong life but do not clear the integrated provirus, so they are not a cure.
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About AIDS and HIV Infection
HIV is a retrovirus that infects CD4 T lymphocytes and gradually weakens immune function, while AIDS is the advanced syndrome caused by severe immune deficiency. Coverage includes viral transmission, replication, disease progression, opportunistic infections, diagnosis, prevention and the difference between HIV infection and AIDS.
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