All of the following statements regarding biovailability of a drug are true except______________?
Correct answer: C. Low oral biovailability always and necessarily mean poor absorption
- A. It is the proportion (fraction) of unchanged drug that reaches the systemic circulation
- B. Biovailability of an orally administered drug can be calculated by comparing the area under cure (o-a) after oral and intravenous (IV) administration
- C. Low oral biovailability always and necessarily mean poor absorption
- D. Biovailability can be determined from plasma concentration or urinary excretion data
Explanation
Low oral bioavailability does not necessarily mean poor absorption because extensive first-pass metabolism or chemical degradation can also reduce the amount reaching systemic circulation. Bioavailability is estimated using plasma concentration or urinary excretion, commonly by comparing oral and IV AUC.
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