A patient taking a medicine metabolised by liver enzymes begins another medicine that inhibits those enzymes. Which effect is most likely?
Correct answer: B. A higher blood level of the first medicine
- A. A lower blood level of the first medicine
- B. A higher blood level of the first medicine
- C. A faster renal excretion of the first medicine
- D. A complete loss of absorption of the first medicine
Explanation
Enzyme inhibition slows the metabolism of the affected medicine, so its blood concentration may rise and toxicity may occur. Enzyme induction generally has the opposite effect by increasing metabolism.
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About Principles of Pharmacology
Pharmacology examines drug sources, names, dosage forms, mechanisms of action, absorption, distribution, metabolism and excretion. Questions cover pharmacokinetics versus pharmacodynamics, therapeutic effects, adverse reactions, contraindications, drug interactions, tolerance, dependence and the safety responsibilities of the nurse.
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