Fairly easy

A patient is prescribed amitriptyline for chronic neuropathic pain. Which instruction is most appropriate?

Correct answer: A. Rise slowly from sitting or lying positions

  • A. Rise slowly from sitting or lying positions
  • B. Stop the medicine when pain first improves
  • C. Take extra tablets for sudden severe pain
  • D. Expect increased saliva after each dose

Explanation

Amitriptyline can cause postural hypotension, so rising slowly helps prevent dizziness and falls. It also commonly causes sedation, dry mouth and constipation, and it should not be stopped suddenly or used as an unscheduled rescue analgesic.

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About Analgesics and CNS Drugs

This area covers opioid and non-opioid analgesics, local anaesthetics, sedatives, anxiolytics, antidepressants, antipsychotics, antiepileptics and drugs for Parkinsonism. It examines therapeutic actions, dependence, respiratory depression, extrapyramidal effects, serotonin related toxicity and the distinction between pain relief, sedation and loss of consciousness.

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