Which of the following X-linked recessive traits is more common in human males than in human females?
Correct answer: A. Hemophilia
- A. Hemophilia
- B. Sickle cell Anemia
- C. Diabetes
- D. Hypophosphatemic rickets
- E. Testicular feminization syndrome
Explanation
Hemophilia is an X-linked recessive disorder that affects blood clotting. It is caused by mutations in the genes that encode clotting factors VIII (hemophilia A) and IX (hemophilia B). Since the gene for hemophilia is located on the X chromosome, males are more likely to inherit the disorder than females. This is because males only have one X chromosome, while females have two X chromosomes. If a male inherits the mutated X chromosome from his mother, he will have hemophilia because he does not have another X chromosome with a normal copy of the clotting factor gene to compensate for the mutated one. In contrast, females would need to inherit two copies of the mutated gene (one from each parent) to develop the disorder, making it less common in females.
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About Inheritance
Mendel's laws explain segregation, independent assortment and the prediction of genetic ratios using alleles, genotypes and phenotypes. The chapter also covers linked genes, recombination and crossing over during meiosis, then applies pedigree reasoning to X-linked recessive traits, which show different inheritance patterns in males and females.
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