Which of the following is an irreversible inhibitor?
Correct answer: A. Cyanide
- A. Cyanide
- B. Anti-cholinesterase
- C. Methanol
- D. Malonic acid
Explanation
Poisons like cyanide are irreversible inhibitors as they destroy the structure of the active sites of the enzymes by forming covalent bonds or physically blocking them. The rest are all reversible inhibitors, which do not damage the active site permanently and their effect can be reversed.
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Enzymes are biological catalysts that lower activation energy without being consumed, and their specificity is explained by the lock and key and induced fit models. Work includes the effects of temperature, pH and substrate concentration on reaction rate, plus competitive and non-competitive inhibition and how these differ.
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