Which of the following incorrectly identifies the mode of inheritance for the given genetic disease?
Correct answer: D. Sickle cell-dominant
- A. Distal symphalangism-dominant
- B. Cystic fibrosis-recessive
- C. Albinism-recessive
- D. Sickle cell-dominant
Explanation
Sickle cell disease is a hereditary disease seen most often among people of African ancestry. Caused by mutations in one of the genes that encode the hemoglobin protein, the disease is inherited as an autosomal recessive trait.
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About Inheritance
Mendel's laws explain segregation, independent assortment and the prediction of genetic ratios using alleles, genotypes and phenotypes. The chapter also covers linked genes, recombination and crossing over during meiosis, then applies pedigree reasoning to X-linked recessive traits, which show different inheritance patterns in males and females.
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Mendel's law states that a random assortment of maternally and paternally derived chromosomes in meiosis results in gametes that have different combinations of these genes.
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