Which of the following derivatives of carboxylic acid is the most reactive towards nucleophilic acyl substitution?
Correct answer: B. Acid halide
- A. Acid amide
- B. Acid halide
- C. Ester
- D. Acid anhydride
Explanation
The reactivity of carboxylic acid derivatives is determined by the leaving group ability of the group attached to the carbonyl. The halide ion (e.g. Cl-) is the best leaving group. among the choices, making the acid halide the most reactive derivative.
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About Carboxylic Acids
Carboxylic acids are named and studied through the combined effects of the carbonyl and hydroxyl groups, their preparation, acidity and hydrogen bonding. Reactions include neutralisation, esterification, reduction and conversion into acid chlorides, anhydrides, esters and amides, with emphasis on how these derivatives interconvert.
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