Which classification of amine will be produced if we react acyl chloride with RNH2?
Correct answer: B. 2o amide
- A. 1o amide
- B. 2o amide
- C. 3o amide
- D. No reaction
Explanation
The reaction between an acyl chloride and a primary amine (RNH2) results in the formation of a 2o amide and HCl. The acyl chloride is highly reactive and undergoes nucleophilic acyl substitution with the amine. A primary amine, when reacted with an acyl chloride, yields a secondary amide because the nitrogen atom of the amine forms a bond with the carbonyl carbon of the acyl chloride, displacing the chloride ion. This reaction is not applicable for the formation of 1o or 3o amides, as they require different starting materials (ammonia for 1o amides and secondary amines for 3o amides). Therefore, the correct answer is a 2o amide.
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About Carboxylic Acids
Carboxylic acids are named and studied through the combined effects of the carbonyl and hydroxyl groups, their preparation, acidity and hydrogen bonding. Reactions include neutralisation, esterification, reduction and conversion into acid chlorides, anhydrides, esters and amides, with emphasis on how these derivatives interconvert.
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