The uptake of glucose by the liver increase following a carbohydrate meal because____________?
Correct answer: B. There is increase in phosphorylation of glucose by glucokinase
- A. GLUT-2 stimulated by insulin
- B. There is increase in phosphorylation of glucose by glucokinase
- C. Glucokinase has a low Km for glucose
- D. Hexokinase in liver has a high affinity for glucose
Explanation
After a carbohydrate-rich meal, hepatic glucose uptake increases because glucokinase phosphorylates more incoming glucose to glucose 6-phosphate, trapping it in the liver. Hepatic glucokinase has a high Km, not a low Km, and GLUT2 is not directly stimulated by insulin.
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