The most reliable single histologic criterion for diagnosis of oral squamous cell carcinoma is____________?

Correct answer: A. Invasion

  • A. Invasion
  • B. Degeneration
  • C. Pleomorphism
  • D. Encpsulation

Explanation

Invasion of malignant epithelial cells through the basement membrane into connective tissue is the decisive histologic evidence of squamous cell carcinoma. Pleomorphism supports malignancy but can also occur in severe dysplasia without invasion.

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