The most prominent toxic effect associated with acetominophen use is______________?
Correct answer: C. Hepatic necrosis
- A. Respiratory alkalosis
- B. Haemorrhage
- C. Hepatic necrosis
- D. Gastric Ulceration
Explanation
The major dose-related toxicity of acetaminophen overdose is hepatic necrosis caused by accumulation of the toxic metabolite NAPQI when hepatic glutathione is depleted. Gastric ulceration and hemorrhage are more characteristic of aspirin and other NSAIDs.
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