The molecular basis of sickle cell anemia was found by:
Correct answer: D. Vernon Ingram
- A. F. Sanger
- B. George Beadle
- C. Edward Tatum
- D. Vernon Ingram
Explanation
The correct answer is Ingram. Vernon Ingram's pioneering work in the 1950s showed that sickle cell anaemia is caused by a single amino acid substitution in the haemoglobin protein. This was a groundbreaking discovery, as it linked a specific molecular defect to a disease. The other options, F. Sanger, Beadle, and Tatum, were instrumental in genetics and biochemistry but did not make this particular discovery related to sickle cell anaemia.
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The chapter covers water's polarity and biological roles, carbohydrates, lipids, proteins and nucleic acids, including their monomers, bonds, structures and functions. It also distinguishes RNA from DNA and explains conjugated molecules such as glycoproteins, glycolipids and nucleoproteins, which combine organic molecules with a non-protein component.
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