The major enzyme involved in the transfer of the phosphate group from ATP to glucose is:

Explanation

The major enzymes involved in the transfer of a phosphate group from ATP to glucose are kinases (Option C). Specifically, the enzyme hexokinase is responsible for catalyzing this phosphorylation reaction, where a phosphate group is transferred from ATP to glucose to form glucose-6-phosphate.The other enzymes listed (isomerase, dehydrogenase, and decarboxylase) are involved in different types of biochemical reactions and are not responsible for this specific phosphorylation step in glucose metabolism.