The major cells infected by HIV are

Explanation

The major cells infected by HIV are CD4+ T lymphocytes (helper T cells), which play a central role in coordinating the immune response. HIV targets these cells by binding to the CD4 receptor and coreceptors (CCR5 or CXCR4) on their surface, leading to viral entry and replication. In addition to CD4+ T cells, HIV can also infect other CD4-bearing cells such as macrophages and dendritic cells, which serve as reservoirs and help in the spread of the virus throughout the body. The progressive loss of CD4+ T cells is the hallmark of HIV infection and ultimately results in immune system failure, leading to AIDS.