The macromolecular hypothesis was largely accepted in the 1920s due to the work of:

Explanation

The correct answer is Staudinger. Hermann Staudinger's work was pivotal in establishing the concept of macromolecules, such as polymers, as large, chain-like molecules composed of repeating units. His hypothesis was initially controversial, but it gained acceptance in the scientific community during the 1920s, fundamentally changing the understanding of chemical structures. Conversely, W.H. Carothers advanced polymer chemistry with his development of nylon, Ziegler and Natta contributed significantly to polymerization techniques in the 1950s, and William Henry Perkin was a pioneer in the dye industry, unrelated to the macromolecular hypothesis.