The lock and key model of enzyme action was proposed by:
Correct answer: B. Emil Fischer
- A. Louis Pasteur
- B. Emil Fischer
- C. Daniel Koshland
- D. Urey Miller
Explanation
Emil Fischer (1890) proposed a Lock and Key model to visualize substrate and enzyme interaction. According to this model, as one specific key can open only a specific lock, in the same manner a specific enzyme can transform only one substrate into products(s). According to Lock and Key Model the active site is a rigid structure. There is no modification or fexibility in the active site before, during or after the enzyme action and it is used only as a template. Later studies did not support this model in all reactions.
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About Enzymes
Enzymes are biological catalysts that lower activation energy without being consumed, and their specificity is explained by the lock and key and induced fit models. Work includes the effects of temperature, pH and substrate concentration on reaction rate, plus competitive and non-competitive inhibition and how these differ.
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