The lock and key hypothesis of enzyme action was proposed by
Correct answer: B. Emil Fischer
- A. Koshland
- B. Emil Fischer
- C. Michaelis
- D. James Sumner
Explanation
Fischer suggested in 1894 that the substrate fits the active site as a key fits a lock, which explained specificity but treated the site as rigid. Koshland's induced fit model replaced it in 1958 by allowing the site to mould itself around the substrate. Sumner is remembered for crystallising urease and proving that enzymes are proteins.
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About Mode of Enzyme Action
Enzyme action depends on the active site forming a temporary enzyme substrate complex, then converting substrate into products with lower activation energy. The lock and key and induced fit models explain specificity and binding, while cofactors and changes in enzyme shape can affect catalysis.
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