The Induced fit model was introduced by Koshland in which of the following year?
Correct answer: C. 1959
- A. 1960
- B. 1961
- C. 1959
- D. 1966
Explanation
The induced-fit model was first proposed by Koshland in 1959 to explain the protein conformational changes in the binding process. This model suggests that an enzyme when binding with its substrate optimizes the interface through physical interactions to form the final complex structure.
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About Enzymes
Enzymes are biological catalysts that lower activation energy without being consumed, and their specificity is explained by the lock and key and induced fit models. Work includes the effects of temperature, pH and substrate concentration on reaction rate, plus competitive and non-competitive inhibition and how these differ.
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