The following adverse effect of penicillin is dose related___________?

Correct answer: D. Encephalopathy

  • A. Skin rash
  • B. Intersititial Nephritis
  • C. Drug fever
  • D. Encephalopathy

Explanation

Penicillin-induced encephalopathy is dose related and is more likely with high intravenous doses or impaired renal clearance. Rash, interstitial nephritis and drug fever are generally hypersensitivity reactions rather than direct dose-dependent toxicity.

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