The deficiency of which of the following causes severe combined immunodeficiency?
Correct answer: D. Adenosine deaminase
- A. Hypoxanthine-guanine transferase
- B. Xanthine oxidase
- C. PRPP synthetase
- D. Adenosine deaminase
Explanation
ADA deficiency leads to SCID, a group of rare, inherited disorders characterized by a severe impairment of both the T and B lymphocytes of the immune system. Adenosine deaminase is involved in the breakdown of purines, and its deficiency results in the accumulation of toxic metabolites. that are particularly harmful to developing immune cells.
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