The class of antibody that appears first in the blood during an infection and is the largest in size is

  • A. IgG
  • B. IgA
  • C. IgM
  • D. IgE

Explanation

IgM is a pentamer, the first antibody deployed in a primary response, while IgG dominates later and crosses the placenta. Knowing one signature feature per class is enough for most options.

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