Somatic mutation of PTEN is seen in________________?
Correct answer: D. Endometrial Carcinoma
- A. Retinoblastoma
- B. Osteosarcoma
- C. Carcinoma breast
- D. Endometrial Carcinoma
Explanation
PTEN is a tumour-suppressor gene regulating the PI3K-AKT pathway, and its somatic loss is particularly associated with endometrial carcinoma. The other listed tumours have different characteristic genetic abnormalities.
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Practise Neoplasia
34 free Neoplasia MCQs from Pathology, each with the correct answer and an explanation. Unlimited attempts, no account needed.
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