SN2 reaction can be best carried out with__________________?
Correct answer: A. primary alkyl halide
- A. primary alkyl halide
- B. secondary alkyl halide
- C. tertiary alkyl halide
- D. all
Explanation
SN2 reactions require backside attack by the nucleophile, so steric hindrance must be small; primary alkyl halides provide the least hindered carbon. Tertiary halides are strongly hindered and generally undergo SN1 or elimination instead. Students may choose secondary halide because it can undergo SN2, but it is less favourable than a primary halide.
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About Nucleophilic Substitution
Nucleophilic substitution replaces a leaving group in an alkyl halide when an electron-rich nucleophile attacks the carbon atom. The topic compares SN1 and SN2 mechanisms, including reaction conditions, substrate structure, solvent effects, nucleophile strength, carbocation formation and stereochemical changes, and distinguishes substitution from elimination.
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