Sickle cell anaemia is induced to:
Correct answer: B. Change of amino acid in b-chain of haemoglobin
- A. Change of amino acid in a-chain of haemoglobin
- B. Change of amino acid in b-chain of haemoglobin
- C. Change of amino acid in both a and b chains of haemoglobin
- D. Change of amino acid either a or b chains of haemoglobin
Explanation
B is is the correct option. Sickle cell anemia is caused by a point mutation in the b-chain of hemoglobin, where the amino acid glutamic acid is replaced by valine. This mutation results in the formation of abnormal hemoglobin known as hemoglobin S (HbS), which can lead to the characteristic sickling of red blood cells and a range of health problems.
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About Inheritance
Mendel's laws explain segregation, independent assortment and the prediction of genetic ratios using alleles, genotypes and phenotypes. The chapter also covers linked genes, recombination and crossing over during meiosis, then applies pedigree reasoning to X-linked recessive traits, which show different inheritance patterns in males and females.
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