Sickle cell anaemia induce to:
Correct answer: B. Change of amino acid in the b-chain of haemoglobin
- A. Change of amino acid in the a-chain of haemoglobin
- B. Change of amino acid in the b-chain of haemoglobin
- C. Change of amino acid in both a and b chains of haemoglobin
- D. Change of amino acid either a or b chains of haemoglobin
Explanation
Sickle cell anemia is a genetic disorder caused by a single nucleotide mutation in the gene encoding the b-chain of hemoglobin. This mutation results in the substitution of valine for glutamic acid at the sixth position of the b-chain. This alteration leads to the formation of hemoglobin S (HbS), which causes red blood cells to deform into a sickle shape under low oxygen conditions.Option B is correct because it accurately describes the site of the mutation. Options A, C, and D are incorrect because they either refer to the wrong chain (a-chain in Option A), both chains which is incorrect (Option C), or suggest variability that does not occur (Option D).
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