Rejection of a transplanted kidney is brought about mainly by
Correct answer: A. T lymphocytes recognising the foreign antigens on the graft
- A. T lymphocytes recognising the foreign antigens on the graft
- B. histamine released by mast cells
- C. phagocytosis by neutrophils alone
- D. the failure of the graft's own blood supply
Explanation
The donor tissue carries different major histocompatibility antigens, and T cells attack the graft as they would a virus infected cell, which is why patients take immunosuppressive drugs for life and why donors are tissue matched first. This is a cell mediated response, so antibody plays a smaller part. A transplant from an identical twin needs no suppression, because the antigens are the same.
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About Specific Defense Mechanism
Specific defense mechanisms provide targeted immunity through B lymphocytes, T lymphocytes, antibodies and memory cells that recognize particular antigens. Questions cover humoral and cell mediated responses, clonal selection, primary and secondary immune responses, vaccination and passive immunity, while distinguishing adaptive defenses from the immediate, non specific innate response.
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