Pick out the correct statements. (1) Haemophilia is a sexlinked recessive disease. (2) Down's syndrome is due to aneuploidy. (3) Phenylketonuria is an autosomal recessive gene disorder. (4) Sickle cell anemia is an X-linked recessive gene disorder.
Correct answer: B. (1), (2) and (3) are correct.
- A. (1), (3) and (4) are correct.
- B. (1), (2) and (3) are correct.
- C. (1) and (4) are correct.
- D. (2) and (4) are correct.
Explanation
Sickle-cell anemia is an autosomal recessive genetic disorder. It can be transmitted from parents to the offspring when both partners are carriers of the gene (or heterozygous). Sickle cell anemia is a genetic condition that has an autosomal recessive inheritance pattern. This means that the condition isn't linked to the sex chromosomes. Someone must receive two copies of a recessive allele in order to have the condition.
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About Inheritance
Mendel's laws explain segregation, independent assortment and the prediction of genetic ratios using alleles, genotypes and phenotypes. The chapter also covers linked genes, recombination and crossing over during meiosis, then applies pedigree reasoning to X-linked recessive traits, which show different inheritance patterns in males and females.
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