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People who have migrated from the planes to a higher altitude area about six months back:

Correct answer: A. Have more RBCs and their hemoglobin has a lower binding affinity to O2 .

  • A. Have more RBCs and their hemoglobin has a lower binding affinity to O2 .
  • B. Are not physically fit to play games like football.
  • C. Suffer from altitude sickness with symptoms like nausea, fatigue, etc.
  • D. Have the usual RBC count but their haemoglobin has a very high binding affinity to O 2.

Explanation

After about six months at high altitude the body acclimatises: it produces more red blood cells (polycythaemia) and raises 2,3-BPG, which shifts the oxygen-haemoglobin curve to the right, lowering haemoglobin's O₂ binding affinity so more O₂ is released to the tissues.

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