Ozone depletion is mainly due to the reaction of ozone (O3) with:

Explanation

Chlorofluorocarbons used as refrigerants in air conditioning and in aerosol sprays are inert in the troposphere but slowly diffuse into stratosphere, where they are subjected to ultraviolet radiation generating ClO free radicals. Chlorofluorocarbons (CFCs) play an effective role in removing O3 in the stratosphere .A single chloride free radical can destroy upto 100,000 ozone molecules.