Lock and key model was proposed by _?
Correct answer: A. Emil Fischer
- A. Emil Fischer
- B. Koshland
- C. Watson and Crick
- D. Rosalind Franklin
Explanation
The lock and key model was proposed by Emil Fischer in 1894. Emil Fischer, a German chemist, introduced this concept in the late 19th century. The lock and key model describes the specificity of enzyme-substrate interactions. The lock and key model helps illustrate the specificity of enzymes for their substrates. It suggests that enzymes have a pre-existing active site with a specific shape and chemical environment that complements the substrate. This model has been valuable in understanding the molecular basis of enzyme-substrate interactions and catalysis. However, it is essential to note that the concept has evolved, and the induced fit model provides a more accurate description of enzyme-substrate binding.
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About Enzymes
Enzymes are biological catalysts that lower activation energy without being consumed, and their specificity is explained by the lock and key and induced fit models. Work includes the effects of temperature, pH and substrate concentration on reaction rate, plus competitive and non-competitive inhibition and how these differ.
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