Lock and key model (1890), was modified by
Correct answer: C. Koshland
- A. Emil Fischer
- B. Erwin Chargaff
- C. Koshland
- D. Lorenz Oken
Explanation
The lock and key model was modified by the induced fit model, proposed by Daniel Koshland in 1958. Unlike the rigid "lock and key" model, the induced fit model suggests that the enzyme's active site is flexible and molds itself around the substrate upon binding, improving the fit and catalytic efficiency.
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About Enzymes
Enzymes are biological catalysts that lower activation energy without being consumed, and their specificity is explained by the lock and key and induced fit models. Work includes the effects of temperature, pH and substrate concentration on reaction rate, plus competitive and non-competitive inhibition and how these differ.
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