Koshland's induced fit model improved on the lock and key hypothesis by proposing that
Correct answer: D. the active site moulds itself around the substrate as it binds
- A. the active site is completely rigid
- B. the substrate changes its shape before binding
- C. enzymes have no binding site at all
- D. the active site moulds itself around the substrate as it binds
Explanation
Koshland argued in 1966 that binding itself induces a conformational change that tightens the fit and stresses bonds in the substrate, whereas the older lock and key model pictured the active site as a fixed shape. Both models agree that the fit is specific.
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About Characteristics of Enzymes
Enzymes are globular biological catalysts that lower activation energy without being consumed, usually showing specificity for particular substrates. Questions cover active sites, enzyme substrate complexes, the lock and key and induced fit models, intracellular and extracellular action, and the effects of denaturation, while distinguishing enzymes from non biological catalysts.
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