Koshland's induced fit model improved on the lock and key hypothesis by proposing that
- A. the active site is completely rigid
- B. the substrate changes its shape before binding
- C. enzymes have no binding site at all
- D. the active site moulds itself around the substrate as it binds
Explanation
Koshland argued in 1966 that binding itself induces a conformational change that tightens the fit and stresses bonds in the substrate, whereas the older lock and key model pictured the active site as a fixed shape. Both models agree that the fit is specific.
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