Insulin caused lipogenesis by all except____________?
Correct answer: B. Inhibits Pyruvate dehydrogenase
- A. Increasing acetyl-CoA corboxylase activity
- B. Inhibits Pyruvate dehydrogenase
- C. Increases the transport of glucose in to the cells
- D. Decreases intracellular cAMP level
Explanation
Insulin stimulates, rather than inhibits, pyruvate dehydrogenase, increasing acetyl-CoA supply for fatty-acid synthesis. It also increases glucose uptake, activates acetyl-CoA carboxylase and lowers intracellular cAMP.
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