In immunoglobulins / antibodies, Two light chains and two heavy chains are linked to each other by:
Correct answer: D. Disulphide bonds
- A. Covalent bonds
- B. Hydrogen bonds
- C. Ionic bonds
- D. Disulphide bonds
Explanation
Each antibody is made up of two short light (L) peptide chains and two long heavy (H) peptide chains (H2L2) joined to each other by disulfide bonds. Disulfide bonds are covalent linkages between the sulphur-containing side chains of cysteine amino acids.The peptide chains are arranged in a Y shaped structure. Each chain in the antibody has both constant and variable regions. The amino acid sequence and conformation of the variable region keeps changing from one type of antibody to the other. The conformation and amino acid sequence of the constant region remains the same. The unique antigen binding site in each antibody that is compatible with specific antigens is composed of the variable regions of both the heavy and the light chains.
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