In higher vertebrates, the immune system can distinguish between self-cells and non-self-cells. If this property is lost due to genetic abnormality and it attacks self-cells, then it leads to:

Explanation

Autoimmunity is a disorder of the body's defense mechanisms in which an immune response is elicited against its own tissues, which are thereby damaged or destroyed. Autoimmunity may be caused due to genetic or environmental factors. This immune system dysfunction can result in a wide range of symptoms and health problems. There are more than 80 known autoimmune diseases, and they can affect virtually any part of the body.