Hypercalcemia associated with malignancy is most often mediated by _____________?
Correct answer: A. Parathyroid hormone related protein (PTHrP)
- A. Parathyroid hormone related protein (PTHrP)
- B. Parathyroid hormone ( PTH)
- C. Interleukin - 6 ( IL- 6)
- D. Calcitonin
Explanation
Many cancers, especially squamous-cell carcinomas, secrete PTH-related protein, which mimics PTH by increasing bone resorption and renal calcium retention. This humoral mechanism is more common than secretion of authentic PTH by the tumour.
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