Hydroxylation of proline require the following except____________?
Correct answer: B. Succinate
- A. Fe+2
- B. Succinate
- C. Ascorbic acid
- D. O2
Explanation
Prolyl hydroxylase requires ferrous iron, molecular oxygen and vitamin C to hydroxylate proline residues in collagen. Succinate is not a required cofactor; the related substrate is alpha-ketoglutarate.
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