How does pyruvate enter the 'Krebs cycle' after glycolysis?
Correct answer: B. Acetyl CoA
- A. Pyruvic acid
- B. Acetyl CoA
- C. Carbon dioxide
- D. Both A and B
Explanation
Option B is correct since, for pyruvate, the product of glycolysis, to enter the next pathway, it must undergo several changes to become 'acetyl Coenzyme A' (acetyl CoA). Pyruvate enters the Krebs cycle after glycolysis in the form of acetyl-CoA. After glycolysis, pyruvate is transported from the cytoplasm of the cell into the mitochondrial matrix, where it undergoes Pyruvic Acid Oxidation. In the presence of oxygen, pyruvate is first converted into acetyl-CoA by a complex of enzymes known as the pyruvate dehydrogenase complex.
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About Bioenergetics
Cellular respiration explains how cells release energy from glucose through glycolysis, the link reaction, Krebs cycle and electron transport chain. It includes ATP production, substrate-level and oxidative phosphorylation, aerobic versus anaerobic respiration, and the roles of mitochondria, oxygen and fermentation in energy transfer.
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