Enzymes such as pepsin and trypsin are secreted in an inactive form known as a

  • A. coenzyme
  • B. cofactor
  • C. prosthetic group
  • D. zymogen

Explanation

A zymogen, or proenzyme, carries an extra length of polypeptide that blocks the active site, and removing it activates the enzyme once it has reached the place where it is needed. This prevents a protease from digesting the very cells that made it, and failure of the mechanism in the pancreas causes the self digestion seen in acute pancreatitis. Coenzymes and cofactors are helper molecules, not inactive precursors.

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