Enzymes lower the activation energy by stabilizing the transition state of a metabolic reaction due to?

Explanation

Enzymes lower the activation energy by changing conditions within the active site. The active site of an enzyme is the specific region where the substrate binds and the catalytic reaction takes place. Enzymes can alter the local environment within the active site to create optimal conditions for the reaction to occur. This may involve providing specific chemical groups or ions, adjusting pH or temperature, or creating a suitable 3D arrangement of the substrate molecules. By modifying these conditions, enzymes stabilize the transition state of the reaction, making it easier for the reaction to proceed.