During the rising phase of a typical mammalian neuronal action potential, which event occurs first?
Correct answer: D. Rapid sodium entry through voltage-gated channels
- A. Chloride release from the axon
- B. Rapid potassium entry through ligand-gated channels
- C. Calcium removal from the synaptic cleft
- D. Rapid sodium entry through voltage-gated channels
Explanation
Depolarisation begins when voltage-gated sodium channels open and sodium enters the neuron down its electrochemical gradient. Potassium efflux is more important during repolarisation, not the initial rising phase.
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